Winter 2001

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چکیده

Based on research conducted by NCBI’s comparative genomics group, the database of Clusters of Orthologous Groups of proteins (COGs) represents a phylogenetic classification of proteins encoded in complete genomes. The COGs are derived from an “all-against-all” sequence comparison of the encoded proteins. Each COG consists of individual proteins or groups of paralogs from at least three lineages and is therefore considered to correspond to an ancient conserved domain. The database is designed to support research on genome evolution as well as functional annotation of genomes.

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تاریخ انتشار 2002